abstract：:The U.S. Food and Drug Administration (FDA) Amendments Act of 2007 mandated that the FDA develop a system for using automated health care data to identify risks of marketed drugs and other medical products. The Observational Medical Outcomes Partnership is a public-private partnership among the FDA, academia, data own...

journal_title：Annals of internal medicine

authors： Stang PE,Ryan PB,Racoosin JA,Overhage JM,Hartzema AG,Reich C,Welebob E,Scarnecchia T,Woodcock J

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:No regulations govern placebo composition. The composition of placebos can influence trial outcomes and merits reporting. PURPOSE:To assess how often investigators specify the composition of placebos in randomized, placebo-controlled trials. DATA SOURCES:4 English-language general and internal medicine jou...

journal_title：Annals of internal medicine

authors： Golomb BA,Erickson LC,Koperski S,Sack D,Enkin M,Howick J

更新日期：2010-10-19 00:00:00

abstract：:This issue provides a clinical overview of Clostridium difficile infection focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In th...

journal_title：Annals of internal medicine

authors： Hessen MT

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Mucositis can be a serious complication of cancer treatment. Palifermin reduces mucositis when given in multiple doses to patients undergoing hematopoietic stem-cell transplantation. OBJECTIVE:To evaluate the efficacy of palifermin given as a single dose before each cycle in patients receiving multicycle ch...

journal_title：Annals of internal medicine

authors： Vadhan-Raj S,Trent J,Patel S,Zhou X,Johnson MM,Araujo D,Ludwig JA,O'Roark S,Gillenwater AM,Bueso-Ramos C,El-Naggar AK,Benjamin RS

更新日期：2010-09-21 00:00:00

abstract：:The scope of recent literature on the concept of "vulnerable plaque" was reviewed by examining 463 abstracts of primary and review articles identified through MEDLINE (2003 to April 2010). Proposed definition criteria of vulnerable plaque included active inflammation, a thin cap with a large lipid core, endothelial de...

journal_title：Annals of internal medicine

authors： Alsheikh-Ali AA,Kitsios GD,Balk EM,Lau J,Ip S

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:It is unclear whether patients understand that percutaneous coronary intervention (PCI) reduces only chronic stable angina and not myocardial infarction (MI) or associated mortality. OBJECTIVE:To compare cardiologists' and patients' beliefs about PCI. DESIGN:Survey. SETTING:Academic center. PARTICIPANTS:...

journal_title：Annals of internal medicine

authors： Rothberg MB,Sivalingam SK,Ashraf J,Visintainer P,Joelson J,Kleppel R,Vallurupalli N,Schweiger MJ

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Posttransplantation acute renal failure (ARF) occurs in roughly 25% of recipients of organs from deceased donors. Inflammation in the donor organ is associated with risk for ARF. OBJECTIVE:To determine whether administering corticosteroids to deceased organ donors reduces the incidence and duration of ARF i...

journal_title：Annals of internal medicine

authors： Kainz A,Wilflingseder J,Mitterbauer C,Haller M,Burghuber C,Perco P,Langer RM,Heinze G,Oberbauer R

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:Clinical trial registries are in widespread use to promote transparency around trials and their results. OBJECTIVE:To describe characteristics of drug trials listed in ClinicalTrials.gov and examine whether the funding source of these trials is associated with favorable published outcomes. DESIGN:An observ...

journal_title：Annals of internal medicine

authors： Bourgeois FT,Murthy S,Mandl KD

更新日期：2010-08-03 00:00:00

abstract：:The systemic capillary leak syndrome (SCLS) is a rare disease of reversible plasma extravasation and vascular collapse accompanied by hemoconcentration and hypoalbuminemia. Its cause is unknown, although it is believed to be a manifestation of transient endothelial dysfunction due to endothelial contraction, apoptosis...

journal_title：Annals of internal medicine

authors： Druey KM,Greipp PR

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Extended-duration low-molecular-weight heparin has been shown to prevent venous thromboembolism (VTE) in high-risk surgical patients. OBJECTIVE:To evaluate the efficacy and safety of extended-duration enoxaparin thromboprophylaxis in acutely ill medical patients. DESIGN:Randomized, parallel, placebo-contro...

journal_title：Annals of internal medicine

authors： Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Nicol P,Vicaut E,Turpie AG,Yusen RD,EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study.

更新日期：2010-07-06 00:00:00

abstract：:The earthquake that struck Haiti in January 2010 caused an estimated 230,000 deaths and injured approximately 250,000 people. The Israel Defense Forces Medical Corps Field Hospital was fully operational on site only 89 hours after the earthquake struck and was capable of providing sophisticated medical care. During th...

journal_title：Annals of internal medicine

authors： Kreiss Y,Merin O,Peleg K,Levy G,Vinker S,Sagi R,Abargel A,Bartal C,Lin G,Bar A,Bar-On E,Schwaber MJ,Ash N

更新日期：2010-07-06 00:00:00

abstract：BACKGROUND:Some health plans profile physicians on the basis of their relative costs and use these profiles to assign physicians to cost categories. Physician organizations have questioned whether the rules used to attribute costs to a physician affect the cost category to which that physician is assigned. OBJECTIVE:T...

journal_title：Annals of internal medicine

authors： Mehrotra A,Adams JL,Thomas JW,McGlynn EA

更新日期：2010-05-18 00:00:00

abstract：BACKGROUND:Neurologic complications of endocarditis can influence diagnosis, therapeutic plans, and prognosis. OBJECTIVE:To describe how early cerebral magnetic resonance imaging (MRI) affects the diagnosis and management of endocarditis in hospitalized adults. DESIGN:Single-center prospective study between June 2005...

journal_title：Annals of internal medicine

authors： Duval X,Iung B,Klein I,Brochet E,Thabut G,Arnoult F,Lepage L,Laissy JP,Wolff M,Leport C,IMAGE (Resonance Magnetic Imaging at the Acute Phase of Endocarditis) Study Group.

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Women treated with therapeutic chest radiation may develop breast cancer. PURPOSE:To summarize breast cancer risk and breast cancer surveillance in women after chest radiation for pediatric or young adult cancer. DATA SOURCES:Studies from MEDLINE, EMBASE, the Cochrane Library, and CINAHL (1966 to December ...

journal_title：Annals of internal medicine

authors： Henderson TO,Amsterdam A,Bhatia S,Hudson MM,Meadows AT,Neglia JP,Diller LR,Constine LS,Smith RA,Mahoney MC,Morris EA,Montgomery LL,Landier W,Smith SM,Robison LL,Oeffinger KC

更新日期：2010-04-06 00:00:00

abstract：:Concierge medical practices, which advertise expanded access to care and individualized attention, collect charges both from insurance companies and directly from their patients. Some bill hundreds of dollars for one-time "executive" physicals, whereas others have patients pay annual retainer fees. Yet, virtually no d...

journal_title：Annals of internal medicine

authors： Stillman M

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Tobacco dependence is a chronic, relapsing condition that may require extended treatment. OBJECTIVE:To assess whether extended-duration transdermal nicotine therapy increases abstinence from tobacco more than standard-duration therapy in adult smokers. DESIGN:Parallel randomized, placebo-controlled trial f...

journal_title：Annals of internal medicine

authors： Schnoll RA,Patterson F,Wileyto EP,Heitjan DF,Shields AE,Asch DA,Lerman C

更新日期：2010-02-02 00:00:00

abstract：BACKGROUND:The pandemic potential of influenza A (H5N1) virus is a prominent public health concern of the 21st century. OBJECTIVE:To estimate the effectiveness and cost-effectiveness of alternative pandemic (H5N1) mitigation and response strategies. DESIGN:Compartmental epidemic model in conjunction with a Markov mod...

journal_title：Annals of internal medicine

authors： Khazeni N,Hutton DW,Garber AM,Owens DK

更新日期：2009-12-15 00:00:00

abstract：:The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic f...

journal_title：Annals of internal medicine

authors： McDermott MT

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Adherence to short-term continuous positive airway pressure (CPAP) may predict long-term use. Unfortunately, initial CPAP intolerance may lead to poor adherence or abandonment of therapy. OBJECTIVE:To determine whether a short course of eszopiclone at the onset of therapy improves long-term CPAP adherence m...

journal_title：Annals of internal medicine

authors： Lettieri CJ,Shah AA,Holley AB,Kelly WF,Chang AS,Roop SA,CPAP Promotion and Prognosis-The Army Sleep Apnea Program Trial.

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Despite convincing evidence that lowering blood pressure decreases cardiovascular morbidity and mortality, the hypertension burden remains high and control rates are poor in developing countries. OBJECTIVE:To assess the effectiveness of 2 community-based interventions on blood pressure in hypertensive adult...

journal_title：Annals of internal medicine

authors： Jafar TH,Hatcher J,Poulter N,Islam M,Hashmi S,Qadri Z,Bux R,Khan A,Jafary FH,Hameed A,Khan A,Badruddin SH,Chaturvedi N,Hypertension Research Group.

更新日期：2009-11-03 00:00:00

abstract：DESCRIPTION:New recommendation from the U.S. Preventive Services Task Force (USPSTF) on the use of nontraditional, or novel, risk factors in assessing the coronary heart disease (CHD) risk of asymptomatic persons. METHODS:Systematic reviews were conducted of literature since 1996 on 9 proposed nontraditional markers o...

journal_title：Annals of internal medicine

authors： U.S. Preventive Services Task Force.

更新日期：2009-10-06 00:00:00

abstract：BACKGROUND:Retail clinics are an increasingly popular source for medical care. Concerns have been raised about the effect of these clinics on the cost, quality, and delivery of preventive care. OBJECTIVE:To compare the care received at retail clinics for 3 acute conditions with that received at other care settings. D...

journal_title：Annals of internal medicine

authors： Mehrotra A,Liu H,Adams JL,Wang MC,Lave JR,Thygeson NM,Solberg LI,McGlynn EA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases. OBJECTIVE:To compare the benefits and side effects of TwHF extract with those of sulfasalazine for the treatment of active rheumatoid arthritis. DESIGN:Ra...

journal_title：Annals of internal medicine

authors： Goldbach-Mansky R,Wilson M,Fleischmann R,Olsen N,Silverfield J,Kempf P,Kivitz A,Sherrer Y,Pucino F,Csako G,Costello R,Pham TH,Snyder C,van der Heijde D,Tao X,Wesley R,Lipsky PE

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:HIV-1 genotypic and phenotypic susceptibility testing (GPT) optimizes antiretroviral selection, but its effect on survival is unknown. OBJECTIVE:To evaluate the association between GPT and survival. DESIGN:Cohort study. SETTING:10 U.S. HIV clinics. PATIENTS:2699 HIV-infected patients eligible for GPT (pl...

journal_title：Annals of internal medicine

authors： Palella FJ Jr,Armon C,Buchacz K,Cole SR,Chmiel JS,Novak RM,Wood K,Moorman AC,Brooks JT,HOPS (HIV Outpatient Study) Investigators.

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:Without population-based evidence, some clinicians recommend short-term suspension of hormone therapy to improve the performance of mammography. Hormone therapy increases breast density, and abnormal screening mammograms are more common among women with denser breasts and among women using hormone therapy. ...

journal_title：Annals of internal medicine

authors： Buist DS,Anderson ML,Reed SD,Aiello Bowles EJ,Fitzgibbons ED,Gandara JC,Seger D,Newton KM

更新日期：2009-06-02 00:00:00

abstract：:Medical school graduates are avoiding primary care. The very aspects that once attracted students have been subverted. The breadth of practice that was once appealing has become the breadth of heavy-handed scrutiny, as politicians and business leaders have demanded quality--simplistically defined as dogmatic adherence...

journal_title：Annals of internal medicine

authors： Norenberg DD

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:The news media are often criticized for exaggerated coverage of weak science. Press releases, a source of information for many journalists, might be a source of those exaggerations. OBJECTIVE:To characterize research press releases from academic medical centers. DESIGN:Content analysis. SETTING:Press rele...

journal_title：Annals of internal medicine

authors： Woloshin S,Schwartz LM,Casella SL,Kennedy AT,Larson RJ

更新日期：2009-05-05 00:00:00

abstract：BACKGROUND:Use of proton-pump inhibitors in the management of peptic ulcer bleeding is controversial because discrepant results have been reported in different ethnic groups. OBJECTIVE:To determine whether intravenous esomeprazole prevents recurrent peptic ulcer bleeding better than placebo in a multiethnic patient sa...

journal_title：Annals of internal medicine

authors： Sung JJ,Barkun A,Kuipers EJ,Mössner J,Jensen DM,Stuart R,Lau JY,Ahlbom H,Kilhamn J,Lind T,Peptic Ulcer Bleed Study Group.

更新日期：2009-04-07 00:00:00

abstract：:The coverage, cost, and quality problems of the U.S. health care system are evident. Sustainable health care reform must go beyond financing expanded access to care to substantially changing the organization and delivery of care. The FRESH-Thinking Project (www.fresh-thinking.org) held a series of workshops during whi...

journal_title：Annals of internal medicine

authors： Arrow K,Auerbach A,Bertko J,Brownlee S,Casalino LP,Cooper J,Crosson FJ,Enthoven A,Falcone E,Feldman RC,Fuchs VR,Garber AM,Gold MR,Goldman D,Hadfield GK,Hall MA,Horwitz RI,Hooven M,Jacobson PD,Jost TS,Kotlikoff LJ

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Smokers with medical illnesses are at particular risk for complications caused by tobacco. Clinical trial data on the effectiveness of triple-combination pharmacotherapy for tobacco dependence treatment in these high-risk smokers are not available. OBJECTIVE:To evaluate extended duration of a triple-medicat...

journal_title：Annals of internal medicine

authors： Steinberg MB,Greenhaus S,Schmelzer AC,Bover MT,Foulds J,Hoover DR,Carson JL

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Life space is a measure of where a person goes, the frequency of going there, and the dependency in getting there. It may be a more accurate measure of mobility in older adults because it reflects participation in society as well as physical ability. OBJECTIVE:To assess effects of hospitalization on life sp...

journal_title：Annals of internal medicine

authors： Brown CJ,Roth DL,Allman RM,Sawyer P,Ritchie CS,Roseman JM

更新日期：2009-03-17 00:00:00

abstract：BACKGROUND:Valid measurement of physician performance requires accurate identification of patients for whom a physician is responsible. Among all patients seen by a physician, some will be more strongly connected to their physician than others, but the effect of connectedness on measures of physician performance is not...

journal_title：Annals of internal medicine

authors： Atlas SJ,Grant RW,Ferris TG,Chang Y,Barry MJ

更新日期：2009-03-03 00:00:00

abstract：:The U.S. Preventive Services Task Force (USPSTF) seeks to provide reliable and accurate evidence-based recommendations to primary care clinicians. However, clinicians indicate frustration with the lack of guidance provided by the USPSTF when the evidence is insufficient to make a recommendation. This article describes...

journal_title：Annals of internal medicine

authors： Petitti DB,Teutsch SM,Barton MB,Sawaya GF,Ockene JK,DeWitt T,U.S. Preventive Services Task Force.

更新日期：2009-02-03 00:00:00

abstract：BACKGROUND:Variants in genes involved in warfarin metabolism and sensitivity affect individual warfarin requirements and the risk for bleeding. Testing for these variant alleles might allow more personalized dosing of warfarin during the induction phase. In 2007, the U.S. Food and Drug Administration changed the labeli...

journal_title：Annals of internal medicine

authors： Eckman MH,Rosand J,Greenberg SM,Gage BF

更新日期：2009-01-20 00:00:00

abstract：:The Advisory Committee on Immunization Practices (ACIP) consists of 15 experts in immunization and related fields, selected by the Secretary of the U.S. Department of Health and Human Services, to provide advice and guidance on control of vaccine-preventable diseases. In its role as a federal advisory committee, the A...

journal_title：Annals of internal medicine

authors： Smith JC,Snider DE,Pickering LK,Advisory Committee on Immunization Practices.

更新日期：2009-01-06 00:00:00

abstract：:Tax incentives can provide a large financial impetus to change behavior. Current U.S. law establishes a substantial discontinuity in the amount of estate tax that many patients will have to pay in 2010: During this year only, the tax rate drops to zero. This article discusses concerns regarding the sharp change in tax...

journal_title：Annals of internal medicine

authors： Mendenhall GS

更新日期：2008-12-02 00:00:00

abstract：:It is well recognized that physicians' relationships with their patients can have healing effects, but the skills in this area of medical practice are understudied. This article reports on research designed to identify a core set of healing skills. The authors interviewed 50 practitioners, who were identified by their...

journal_title：Annals of internal medicine

authors： Churchill LR,Schenck D

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension. OBJECTIVE:To investigate the effect of adding oral sildenafil to long-term intravenous epoprostenol in patients with pulmonary arterial hypertension. DESIGN:A 16-week...

journal_title：Annals of internal medicine

authors： Simonneau G,Rubin LJ,Galiè N,Barst RJ,Fleming TR,Frost AE,Engel PJ,Kramer MR,Burgess G,Collings L,Cossons N,Sitbon O,Badesch DB,PACES Study Group.

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:Despite advances in prevention and treatment, sexually transmitted infections (STIs) remain an important cause of morbidity and mortality in the United States. PURPOSE:To systematically review the evidence for behavioral counseling interventions to prevent STIs in adolescents and adults (nonpregnant and pre...

journal_title：Annals of internal medicine

authors： Lin JS,Whitlock E,O'Connor E,Bauer V

更新日期：2008-10-07 00:00:00

abstract：DESCRIPTION:The American College of Physicians (ACP) developed this guideline to present the available evidence on various pharmacologic treatments to prevent fractures in men and women with low bone density or osteoporosis. METHODS:Published literature on this topic was identified by using MEDLINE (1966 to December 2...

journal_title：Annals of internal medicine

authors： Qaseem A,Snow V,Shekelle P,Hopkins R Jr,Forciea MA,Owens DK,Clinical Efficacy Assessment Subcommittee of the American College of Physicians.

更新日期：2008-09-16 00:00:00